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Effect of estradiol on oocyte development
Author(s) -
Bianco Katherine,
Mahutte Neal G.,
Arici Aydin,
Sakkas Denny,
Taylor Hugh S.
Publication year - 2009
Publication title -
international journal of gynecology and obstetrics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.895
H-Index - 97
eISSN - 1879-3479
pISSN - 0020-7292
DOI - 10.1016/j.ijgo.2008.10.015
Subject(s) - oocyte , medicine , embryo transfer , andrology , pregnancy rate , pregnancy , oocyte donation , embryo , gynecology , endocrinology , biology , genetics
Objective To determine whether elevated serum estradiol (E 2 ) concentrations in oocyte donors affect assisted reproduction outcome. Method In a retrospective cohort study of 58 consecutive oocyte donation cycles, donors were stratified into 2 groups according to E 2 concentration, group 1 (n = 32; E 2 ≤ 2000 pg/mL [range 456–2000 pg/mL]) and group 2 (n = 27; E 2 > 2000 pg/mL [range, 2062–6957 pg/mL]). Data were analyzed using the t test and χ 2 test. Results Donors in group 1 produced significantly less oocytes than donors in group 2 (19.3 ± 1.7 vs 12.0 ± 1.4; P < 0.001), and recipients of oocytes from group 1 had significantly fewer numbers of embryos available for transfer (10.4 ± 1.1 vs 6.4 ± 0.8; P = 0.003). However, the mean number (3.3) of embryos transferred and the pregnancy rate were the same in both groups. Conclusion Elevated estradiol concentration in oocyte donors did not affect pregnancy outcome, suggesting that estradiol levels in donors do not affect oocyte development.