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Outcomes of pregnancies complicated by beta‐thalassemia/hemoglobin E disease
Author(s) -
Luewan Suchaya,
Srisupundit Kasemsri,
Tongsong Theera
Publication year - 2009
Publication title -
international journal of gynecology and obstetrics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.895
H-Index - 97
eISSN - 1879-3479
pISSN - 0020-7292
DOI - 10.1016/j.ijgo.2008.10.012
Subject(s) - medicine , beta thalassemia , thalassemia , hemoglobin e , disease , hemoglobin , obstetrics , hemoglobinopathy , pregnancy , pediatrics , genetics , biology
Objective To assess the outcomes of pregnancies affected by beta‐thalassemia/hemoglobin E (β‐thal/HbE) disease. Methods A retrospective cohort study was conducted with 54 women with singleton pregnancies complicated by β‐thal/HbE disease only. The controls‐to‐cases ratio was 2:1. Results Although maternal outcomes were similar in both groups, gestational age at birth and birth weight were significantly lower in the study group and the cesarean delivery rate was significantly higher in that group (relative risk [RR], 2.1). The incidences of fetal growth restriction, preterm birth, and low birth weight were also significantly higher in the study group, with RRs of 2.8, 2.7, and 5.6, respectively. Conclusion Pregnancies affected by β‐thal/HbE disease were significantly associated with an increased risk of fetal growth restriction, preterm birth, and low birth weight.