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Intravenous salbutamol for external cephalic version
Author(s) -
Vani Subramaniam,
Lau Soon Yen,
Lim Boon Kiong,
Omar Siti Zawiah,
Tan Peng Chiong
Publication year - 2009
Publication title -
international journal of gynecology and obstetrics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.895
H-Index - 97
eISSN - 1879-3479
pISSN - 0020-7292
DOI - 10.1016/j.ijgo.2008.08.014
Subject(s) - salbutamol , medicine , external cephalic version , anesthesia , bolus (digestion) , intravenous bolus , randomized controlled trial , pregnancy , breech presentation , surgery , asthma , biology , genetics
Objective To evaluate the success of external cephalic version (ECV) using an adjusted bolus dose of intravenous salbutamol compared with no tocolysis. Methods An open‐label randomized study of 114 women with a term breech fetus randomized to receive either an intravenous bolus dose of 0.1 mg salbutamol with further boluses every 5 minutes, as required, before commencing ECV, or no tocolysis. Primary outcomes were successful ECV and rate of cesarean delivery. Results Salbutamol tocolysis resulted in a higher rate of successful ECV compared with no tocolysis (70.2% [40/57] vs 36.8% [21/57]; RR 1.9, 95% CI 1.3–2.8; P < 0.001). Cesarean delivery rate was lower in the salbutamol group compared with the control group (31.6% [18/57] vs 63.2% [36/57]; RR 0.5, 95% CI 0.3–0.8; P = 0.001). Salbutamol dose ranged from 0.1–0.4 mg and outcome was not related to dose. Conclusion Adjusted dose intravenous salbutamol tocolysis prior to ECV increases its success rate and reduces the cesarean delivery rate.