Premium
The influence of body mass index on in vitro fertilization outcome
Author(s) -
Orvieto Raoul,
Meltcer Simion,
Nahum Ravit,
Rabinson Jacob,
Anteby Eyal Y.,
Ashkenazi Jacob
Publication year - 2009
Publication title -
international journal of gynecology and obstetrics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.895
H-Index - 97
eISSN - 1879-3479
pISSN - 0020-7292
DOI - 10.1016/j.ijgo.2008.08.012
Subject(s) - medicine , body mass index , in vitro fertilisation , obesity , pregnancy , obstetrics , gynecology , endocrinology , genetics , biology
Objective To examine whether body mass index (BMI) influences the outcome of in vitro fertilization (IVF). Methods We studied 516 IVF cycles, 438 undergone by nonobese (BMI ≤ 30) and 78 by obese (BMI > 30) women who all had an a priori favorable prognosis (age < 40 years and first, second, or third IVF cycle). Results Pregnancy was achieved in 122 (27.9%) nonobese and 12 (15.4%) obese women. The obese women required significantly longer stimulation and more gonadotropin ampoules, and had lower peak estradiol levels and a significantly lower fertilization rate; obese poor responders had a significantly lower pregnancy rate than nonobese poor responders; and the prevalence of poor responders was significantly higher among obese than nonobese women (28.2% vs 16.9%, P < 0.04). Conclusion While the likelihood of poor responders was increased among obese women, reasonable conception rates were achieved in nonobese poor responders, and were comparable to the rates in nonobese and obese normal responders.