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Effectiveness and safety of loop electrosurgical excision procedure in a low‐resource setting
Author(s) -
Rema Prabhakaran,
Suchetha Sambasivan,
Thara Somanathan,
Fayette Jean Marie,
Wesley Ramani,
Sankaranarayanan Rengaswamy
Publication year - 2008
Publication title -
international journal of gynecology and obstetrics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.895
H-Index - 97
eISSN - 1879-3479
pISSN - 0020-7292
DOI - 10.1016/j.ijgo.2008.06.020
Subject(s) - loop electrosurgical excision procedure , medicine , cervical intraepithelial neoplasia , colposcopy , cryotherapy , cervix , surgery , cure rate , adverse effect , biopsy , punch biopsy , electrosurgery , cervical cancer , radiology , cancer
Objective To evaluate the effectiveness and safety of the loop electrosurgical excision procedure (LEEP) to treat cervical intraepithelial neoplasia (CIN) in a low‐resource setting. Methods Women participating in a cervical screening study in India with histologically confirmed CIN unsuitable for cryotherapy were advised to undergo LEEP. One year after treatment the cervix was visually inspected with acetic acid, followed by colposcopy and biopsy taken from abnormal areas. Cure was defined as no clinical or histologic evidence of CIN. Factors influencing cure rates were evaluated by χ 2 tests. Results Of the 311 women who underwent LEEP, 283 reported for 1‐year follow‐up and 248 (87.6%) were disease free. Cure rates were 93.0% for CIN 1, 85.5% for CIN 2, and 72.7% for CIN 3. Minor adverse effects were observed in 34 women and complications were seen in 5 women. Conclusion LEEP was associated with minimal complications and acceptable cure rates in a low‐resource setting, although women with larger lesions had lower cure rates.