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Progesterone receptor gene polymorphisms are not associated with preterm birth in a Hispanic population
Author(s) -
DiazCueto Laura,
DominguezLopez Pablo,
CantilloCabarcas Julio,
PerezFigueroa Gloria,
ArechavaletaVelasco Miguel,
ArechavaletaVelasco Fabian
Publication year - 2008
Publication title -
international journal of gynecology and obstetrics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.895
H-Index - 97
eISSN - 1879-3479
pISSN - 0020-7292
DOI - 10.1016/j.ijgo.2008.06.008
Subject(s) - linkage disequilibrium , restriction fragment length polymorphism , genotype , genetics , biology , population , allele frequency , progesterone receptor , allele , polymorphism (computer science) , gene , medicine , single nucleotide polymorphism , environmental health , cancer , estrogen receptor , breast cancer
Objective To determine whether increased frequency of mutant alleles of the progesterone receptor gene ( PGR ) was associated with preterm birth in a population of Hispanic women. Methods Placental DNA from 64 patients who had preterm births and 54 control patients was genotyped for 4 progesterone receptor gene polymorphisms by polymerase chain reaction (PCR) restriction fragment length polymorphism. The χ 2 test and t test were used to calculate statistical significance. Linkage disequilibrium was calculated using the Linkage Disequilibrium Analyzer program. Results The genotypic frequencies of the 4 polymorphisms were not significantly different between the study and control groups. In addition, there was complete linkage disequilibrium between V660L, H770H, and PROGINS polymorphisms, but not with + 331G/A polymorphism. Conclusions The present study suggests that polymorphisms in the progesterone receptor gene are unlikely to be associated with an increased risk of preterm birth in a Hispanic population.