Premium
Collagen type 3 alpha 1 polymorphism and risk of pelvic organ prolapse
Author(s) -
Chen HueyYi,
Chung YaWen,
Lin WeiYong,
Wang JiunnChin,
Tsai FuuJen,
Tsai ChangHai
Publication year - 2008
Publication title -
international journal of gynecology and obstetrics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.895
H-Index - 97
eISSN - 1879-3479
pISSN - 0020-7292
DOI - 10.1016/j.ijgo.2008.05.031
Subject(s) - medicine , genotype , restriction fragment length polymorphism , single nucleotide polymorphism , gastroenterology , polymerase chain reaction , polymorphism (computer science) , incidence (geometry) , gynecology , alpha (finance) , surgery , genetics , gene , biology , construct validity , physics , optics , patient satisfaction
Objective To investigate whether pelvic organ prolapse (POP) is associated with collagen 3 alpha 1 ( COL3A1 ) polymorphisms and other factors. Methods A case‐control association study was conducted with 84 women affected with POP and 147 controls. The genotypes of nucleotides COL3A1 rs1800255 and COL3A1 rs1801184 polymorphisms were ascertained by polymerase chain reaction and restriction fragment length polymorphism analysis. Results The distribution of the COL3A1 rs1800255 genotypes was significantly different among affected women and controls. Older age and incidence of COL3A1 rs1800255 genotype AA were significantly associated with risk of POP. Conclusion There may be an association between COL3A1 genotype and risk of POP.