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Platelet‐derived microparticle levels in women with recurrent spontaneous abortion
Author(s) -
Kaptan Kürşat,
Beyan Cengiz,
Ifran Ahmet,
Pekel Aysel
Publication year - 2008
Publication title -
international journal of gynecology and obstetrics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.895
H-Index - 97
eISSN - 1879-3479
pISSN - 0020-7292
DOI - 10.1016/j.ijgo.2008.04.007
Subject(s) - medicine , abortion , platelet , pathogenesis , flow cytometry , platelet activation , gynecology , case control study , obstetrics , immunology , pregnancy , genetics , biology
Objective To investigate the significance of platelet‐derived microparticles (PMPs) in women with recurrent spontaneous abortion. Methods We measured platelet P‐selectin (CD62P) as a platelet activation marker and CD42b + microparticles as PMPs by flow cytometry in whole blood of 20 women with recurrent spontaneous abortion and 20 age‐matched healthy controls with no previous history of spontaneous abortion. Results PMP levels in women with recurrent spontaneous abortion were higher than in women in the control group (4.79 ± 1.18% vs 3.06 ± 0.92%; P < 0.000). CD62P levels were not significantly higher in the study group compared with the control group (13.78 ± 8.62% vs 10.78 ± 7.35%; P > 0.05). Conclusion Our findings suggest that PMPs may have a role in the pathogenesis of recurrent spontaneous abortion.