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Effect of sildenafil on clitoral blood flow and sexual response in postmenopausal women with orgasmic dysfunction
Author(s) -
Cavalcanti Ana L.,
Bagnoli Vicente R.,
Fonseca Ângela M.,
Pastore Roberto A.,
Cardoso Eduardo B.,
Paixão Jucilene S,
Soares José M.,
Saad Fabrício,
Baracat Edmund C.
Publication year - 2008
Publication title -
international journal of gynecology and obstetrics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.895
H-Index - 97
eISSN - 1879-3479
pISSN - 0020-7292
DOI - 10.1016/j.ijgo.2008.03.020
Subject(s) - sildenafil , medicine , placebo , orgasm , female sexual dysfunction , sexual dysfunction , erectile dysfunction , blood flow , placebo group , urology , anesthesia , gynecology , alternative medicine , pathology
Objective To analyze the effects of sildenafil citrate on clitoral blood flow and sexual response in postmenopausal women with orgasmic dysfunction. Method In this randomized, double‐blind, placebo‐controlled trial 22 women received a 50‐mg dose of sildenafil ( n = 11) or placebo ( n = 11) daily for 15 days. The Golombok Rust Inventory of Sexual Satisfaction (GRISS) was used for subjective evaluation of the sexual‐response cycle. Clitoral blood flow was measured by color and pulse Doppler at baseline, after 1 hour of taking the first dose, and after 15 days of treatment. Results Blood flow was significantly more improved in the sildenafil than in the placebo group ( P < 0.05), and a positive correlation between Doppler values and GRISS scores was noted in the sildenafil group after only 15 days of treatment. Conclusion Sildenafil may improve clitoral blood flow and increase the GRISS scores in postmenopausal women with orgasmic dysfunction.