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Effect of folic acid in women with and without insulin resistance who have hyperhomocysteinemic polycystic ovary syndrome
Author(s) -
Kazerooni Talieh,
Asadi Nasrin,
Dehbashi Sedigheh,
Zolghadri Jaleh
Publication year - 2008
Publication title -
international journal of gynecology and obstetrics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.895
H-Index - 97
eISSN - 1879-3479
pISSN - 0020-7292
DOI - 10.1016/j.ijgo.2007.10.024
Subject(s) - medicine , polycystic ovary , insulin resistance , homocysteine , endocrinology , insulin , folic acid
Objective To study the effect of folic acid on homocysteine (Hcy) levels in women with insulin resistance and polycystic ovary syndrome (PCOS) in a prospective clinical trial. Method Of 210 women with PCOS, 70 were hyperhomocysteinemic; and of these, 32 were insulin resistant and 38 were not. The 70 women were treated with folic acid for 3 months. Baseline and serum levels of Hcy and insulin were measured in both groups. Results In both groups Hcy concentrations were significantly decreased following folic acid supplementation. The mean ± SD levels before and after treatment were 14.03 ± 1.5 µmol/L and 12.53 ± 1.72 µmol/L in group 1 ( P < 0.001), and they were 12.07 ± 0.87 µmol/L and 8.83 ± 0.78 µmol/L in group 2 ( P < 0.001). Conclusion The Hcy levels of hyperhomocysteinemic women with PCOS were reduced after 3 months of folic acid supplementation, and the rate of reduction was higher among women without insulin resistance. No change was found in fasting insulin levels.