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Brachial artery responses in menopausal women using tibolone
Author(s) -
CarranzaLira Sebastián,
CuanMartínez Juan R.,
RosalesOrtíz Sergio
Publication year - 2008
Publication title -
international journal of gynecology and obstetrics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.895
H-Index - 97
eISSN - 1879-3479
pISSN - 0020-7292
DOI - 10.1016/j.ijgo.2007.10.022
Subject(s) - tibolone , medicine , brachial artery , pulsatility index , menopause , postmenopausal women , cardiology , artery , blood pressure , genetics , pregnancy , fetus , biology
Objective To determine the effect of tibolone treatment on brachial artery pulsatility index (PI), resistance index (RI), and flux‐mediated dilation (FMD) in postmenopausal Mexican women. Method The FMD, PI, and RI of the right brachial artery were measured in 19 postmenopausal women before and after they received a hyperemic stimulus, first at baseline and then following a 6‐month treatment with 2.5 mg of tibolone per day. Statistical analysis was performed using the t test. Results The mean ± SD age was 52.2 ± 3.9 years; time since menopause was 24.6 ± 16.7 months; and treatment duration was 5.7 ± 2.0 months. Compared with prestimulus measurements, a significant poststimulus increase in arterial diameter and a significant decrease in PI were observed at baseline. Compared with prestimulus measurements, a significant poststimulus increase in arterial diameter and a significant decrease in both PI and RI were observed post‐treatment. Conclusion Tibolone treatment had a favorable effect on brachial artery responses to hyperemic stimuli.