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Chitotriosidase and YKL‐40 in normal and pre‐eclamptic pregnancies
Author(s) -
Madazli Riza,
Kucur Mine,
Gezer Altay,
Isman Ferruh,
Bulut Berk
Publication year - 2008
Publication title -
international journal of gynecology and obstetrics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.895
H-Index - 97
eISSN - 1879-3479
pISSN - 0020-7292
DOI - 10.1016/j.ijgo.2007.09.033
Subject(s) - medicine , umbilical cord , cord blood , fetus , blood pressure , pregnancy , venous blood , eclampsia , prospective cohort study , placenta , endocrinology , obstetrics , immunology , biology , genetics
Objective To compare macrophage activation in normal and pre‐eclamptic pregnancies by determining YKL‐40 concentration and chitotriosidase activity in maternal and cord serum. Methods In this prospective case‐control study samples of maternal peripheral blood and umbilical venous blood were collected from 28 pre‐eclamptic and 24 normotensive pregnant women and their newborns. YKL‐40 concentration and chitotriosidase activity were determined by enzyme‐linked immunoassay and fluorometry, respectively. Results Chitotriosidase activity in maternal and cord serum and YKL‐40 concentration in cord serum were significantly higher in pre‐eclamptic pregnancies ( P < 0.001), but there was no significant difference in maternal serum levels of YKL‐40 between the case and control groups ( P > 0.05). There was a significant positive correlation between diastolic blood pressure and (1) chitotriosidase activity in both maternal and cord serum and (2) cord serum concentration of YKL‐40 ( r = 0.61, r = 0.84, and r = 0.58, respectively). Conclusion This study may be the first to demonstrate maternal and fetal macrophage activation in pre‐eclampsia.