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Vaginal allergic response in women with vulvovaginal candidiasis
Author(s) -
Fan S.R.,
Liao Q.P.,
Liu X.P.,
Liu Z.H.,
Zhang D.
Publication year - 2008
Publication title -
international journal of gynecology and obstetrics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.895
H-Index - 97
eISSN - 1879-3479
pISSN - 0020-7292
DOI - 10.1016/j.ijgo.2007.08.024
Subject(s) - medicine , immunoglobulin e , vulvovaginal candidiasis , immunology , antibody , dermatology , antifungal
Abstract Objective : To determine the concentration of certain cytokines and immunoglobulin (Ig) E in the vaginal lavage fluid (VLF) of women with vulvovaginal candidiasis (VVC). Method : Cytokin and IgE concentrations were measured in the VLF of women with VVC; women free of any genital infections acted as controls. Result : The VLF concentrations of interleukin (IL)‐2, IL‐8, and interferon (INF)‐γ were higher among women with VVC than in the control group; women with severe VVC had a higher VLF concentration of IL‐4 than those with mild to moderate VVC; women with cured VVC had a higher VLF concentration of IL‐13 than did controls; and women with VVC or cured VVC had a higher VLF concentration of IgE than did controls ( P < 0.05 for all). Conclusion : Both helper T cells type 1 and innate response cytokines were shown to play a dominant role in the pathogenesis of VVC. This allergic vaginal response in women with VVC suggests that the form of treatment for VVC should be reconsidered.