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Fatty acids, antioxidants, and oxidative stress in pre‐eclampsia
Author(s) -
Mehendale Savita,
Kilari Anitha,
Dangat Kamini,
Taralekar Vaishali,
Mahadik Sahebarao,
Joshi Sadhana
Publication year - 2008
Publication title -
international journal of gynecology and obstetrics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.895
H-Index - 97
eISSN - 1879-3479
pISSN - 0020-7292
DOI - 10.1016/j.ijgo.2007.08.011
Subject(s) - oxidative stress , medicine , polyunsaturated fatty acid , eclampsia , preeclampsia , lipid peroxidation , antioxidant , fatty acid , cord blood , pathogenesis , endocrinology , pregnancy , biochemistry , biology , genetics
Objective To investigate whether free radical‐mediated membrane lipid peroxidation may be implicated in the pathogenesis of pre‐eclampsia. Methods A prospective study using a sample of 55 healthy pregnant women and 60 pre‐eclamptic women recruited at Bharati Medical Hospital, Pune, India. Maternal and cord samples were examined for (red blood cells and plasma) fatty acid profiles, antioxidants, and oxidative stress levels. Mean values were compared between case and control groups using the t test and Wilcoxon rank test. Results Pre‐eclamptic women showed reduced total omega‐3 fatty acids ( P < 0.05), increased omega‐6:omega‐3 ratio ( P < 0.05), higher oxidative stress ( P < 0.05), and lower antioxidant ( P < 0.05) levels. Similar trends were also observed in cord samples. Conclusion Reduced antioxidants and increased oxidative stress leading to impaired essential polyunsaturated fatty acid levels may be a key factor in the development of pre‐eclampsia.