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Cord blood cardiac troponin I, fetal Doppler velocimetry, and acid base status at birth
Author(s) -
Alexandre Sandra Maria,
D'Almeida Vânia,
Guinsburg Ruth,
Nakamura Mary U.,
Tufik Sérgio,
Moron Antonio
Publication year - 2008
Publication title -
international journal of gynecology and obstetrics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.895
H-Index - 97
eISSN - 1879-3479
pISSN - 0020-7292
DOI - 10.1016/j.ijgo.2007.08.007
Subject(s) - medicine , troponin i , cardiology , fetus , cord blood , umbilical cord , obstetrics , anesthesia , pregnancy , anatomy , biology , myocardial infarction , genetics
Abstract Objective To analyze the association between umbilical cord cardiac troponin I (cTnI), obstetric Doppler, and birth acidemia. Method: This prospective observational study was conducted on 58 singleton pregnancies at 3 Brazilian hospitals. Umbilical and middle cerebral artery Doppler velocimetry were performed 24 h prior to birth. At delivery, cord blood was collected for pH, blood gas analysis, and cTnI measurement. Results: Cardiac troponin I ≥ 0.20 ng/mL was detected in 5 neonates (8.6%). Centralization was recorded in 12 fetuses; 4 of these (33.3%) had detectable cTnI compared with 1/46 (2.2%) fetuses with normal Doppler ( P = 0.005). Acidemia was present in 60% of the neonates with detectable cTnI, compared with 15% of the neonates with undetectable cTnI ( P = 0.042). Conclusion: Centralization and birth acidemia are associated with detectable cTnI in cord blood supporting the possibility of myocardial ischemia in these fetuses.