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Efficacy of levamisole on experimental endometriosis
Author(s) -
Ocal G.,
Kokcu A.,
Cetinkaya M.B.,
Tosun M.,
Kefeli M.,
Kandemir B.
Publication year - 2007
Publication title -
international journal of gynecology and obstetrics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.895
H-Index - 97
eISSN - 1879-3479
pISSN - 0020-7292
DOI - 10.1016/j.ijgo.2007.04.041
Subject(s) - levamisole , saline , medicine , peritoneum , medroxyprogesterone acetate , endometriosis , urology , stromal cell , endocrinology , surgery , estrogen
Objective : To investigate the efficacy of levamisole on experimental endometriosis. Methods : After the implantation of endometrial tissue on abdominal peritoneum, 40 rats were randomized to 1 of 4 equal intervention groups. Levamisole (2 mg/rat) was applied subcutaneously to group “L” once a week. Depot medroxyprogesterone acetate (3 mg/kg) was applied intramuscularly to group “M” twice at 4‐week intervals. Leuprolide (0.075 mg/kg) was applied subcutaneously to group “G” twice at 4‐week intervals. Saline (0.1 cm 3 /rat) was applied subcutaneously to group “C” once a week for 8 weeks. The efficacy of levamisole was determined by volume measurement and characterizing the histological structure of the implants. Result : Volume increase of the implants in group C ( P < 0.05), and volume decrease in groups M, G, and L was found ( P < 0.05, P < 0.01, and P < 0.01, respectively.) Stromal tissue and glandular activity were not different between groups L and G. Conclusion : Levamisole was found to be as effective as leuprolide in regression of the volume of endometriotic implants.