Low‐dose hormone therapy in the perimenopause | Zendy

De Franciscis P. | Zendy; Cobellis L. | Zendy; Fornaro F. | Zendy; Sepe E. | Zendy; Torella M. | Zendy; Colacurci N. | Zendy

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Low‐dose hormone therapy in the perimenopause

Author(s) -

De Franciscis P.,

Cobellis L.,

Fornaro F.,

Sepe E.,

Torella M.,

Colacurci N.

Publication year - 2007

Publication title -

international journal of gynecology and obstetrics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.895

H-Index - 97

eISSN - 1879-3479

pISSN - 0020-7292

DOI - 10.1016/j.ijgo.2007.04.008

Subject(s) - medicine , dydrogesterone , vasomotor , incidence (geometry) , menopause , group b , hormone therapy , gynecology , prospective cohort study , hormone replacement therapy (female to male) , estrogen , breast cancer , physics , cancer , optics , testosterone (patch)

Objective : To evaluate the effects of low‐dose hormone therapy (LD‐HT) on bleeding pattern and vasomotor symptoms in perimenopausal women. Methods : In a prospective, open‐label study at an University clinic, 120 perimenopausal women suffering from irregular menstrual cycles and hot flushes were randomized to micronized 17β‐estradiol 1 mg plus dydrogesterone 10 mg sequential added (LD‐HT; group A: 60 subjects) or dydrogesterone 10 mg from day 15 to 28 (group B: 60 subjects). Number and severity of hot flushes and bleeding pattern were assessed throughout the study. Results : Women in group A experienced a significant reduction in number of hot flushes while no significant variation was observed in group B. The incidence of cyclic bleeding was 86% in group A and 76% in group B, the mean duration was significantly lower in group A than in group B. Conclusions : LD‐HT may control both irregular bleeding and hot flushes in perimenopausal women.

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