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The use of chlorhexidine to reduce maternal and neonatal mortality and morbidity in low‐resource settings
Author(s) -
McClure E.M.,
Goldenberg R.L.,
Brandes N.,
Darmstadt G.L.,
Wright L.L.
Publication year - 2007
Publication title -
international journal of gynecology and obstetrics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.895
H-Index - 97
eISSN - 1879-3479
pISSN - 0020-7292
DOI - 10.1016/j.ijgo.2007.01.014
Subject(s) - medicine , chlorhexidine , psychological intervention , neonatal infection , intensive care medicine , developing country , neonatal mortality , umbilical cord , pregnancy , infant mortality , pediatrics , environmental health , population , nursing , dentistry , biology , economics , genetics , economic growth , anatomy
Of the 4 million neonatal deaths and 500,000 maternal deaths that occur annually worldwide, almost 99% are in developing countries and one‐third are associated with infections. Implementation of proven interventions and targeted research on a select number of promising high‐impact preventative and curative interventions are essential to achieve Millennium Development Goals for reduction of child and maternal mortality. Feasible, simple, low‐cost interventions have the potential to significantly reduce the mortality and severe morbidity associated with infection in these settings. Studies of chlorhexidine in developing countries have focused on three primary uses: 1) intrapartum vaginal and neonatal wiping, 2) neonatal wiping alone, and 3) umbilical cord cleansing. A study of vaginal wiping and neonatal skin cleansing with chlorhexidine, conducted in Malawi in the 1990s suggested that chlorhexidine has potential to reduce neonatal infectious morbidity and mortality. A recent trial of cord cleansing conducted in Nepal also demonstrated benefit. Although studies have shown promise, widespread acceptance and implementation of chlorhexidine use has not yet occurred. This paper is derived in part from data presented at a conference on the use of chlorhexidine in developing countries and reviews the available evidence related to chlorhexidine use to reduce mortality and severe morbidity due to infections in mothers and neonates in low‐resource settings. It also summarizes issues related to programmatic implementation.