Premium
Prevention of recurrent bacterial urinary tract infections by intravesical instillation of hyaluronic acid
Author(s) -
Lipovac M.,
Kurz C.,
Reithmayr F.,
Verhoeven H.C.,
Huber J.C.,
Imhof M.
Publication year - 2007
Publication title -
international journal of gynecology and obstetrics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.895
H-Index - 97
eISSN - 1879-3479
pISSN - 0020-7292
DOI - 10.1016/j.ijgo.2006.11.025
Subject(s) - medicine , hyaluronic acid , urinary system , urology , surgery , retrospective cohort study , gastroenterology , anatomy
Objective : To evaluate the efficacy of vesical instillation of hyaluronic acid against recurrent urinary tract infections. Methods : Twenty women with a history of recurrent urinary tract infections each received 9 intravesical instillations of hyaluronic acid over 6 months. Their status was assessed prospectively over 47.6 weeks and compared with a retrospective review of patient charts covering 36.2 ± 6.2 weeks. Results : The total numbers of urinary tract infections were 67 before and 10 after treatment ( p < 0.001). Thirteen patients (65%) were free of recurrences until the end of the study. One had a recurrence during treatment, and 6 (30%) during follow‐up. The number of infections per year per patient was reduced from 4.99 ± 0.92 to 0.56 ± 0.82 ( p < 0.001). In women with recurrences, time to recurrence was 178.3 ± 25.5 days, compared with 76.7 ± 24.6 days before treatment ( p < 0.001). Conclusion : Intravesical instillation of hyaluronic acid is effective in preventing recurrent urinary tract infections.