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Intrauterine lidocaine plus buccal misoprostol in the endometrial biopsy
Author(s) -
Güney M.,
Oral B.,
Mungan T.
Publication year - 2007
Publication title -
international journal of gynecology and obstetrics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.895
H-Index - 97
eISSN - 1879-3479
pISSN - 0020-7292
DOI - 10.1016/j.ijgo.2006.11.017
Subject(s) - medicine , lidocaine , misoprostol , placebo , visual analogue scale , anesthesia , curette , buccal administration , endometrial biopsy , surgery , endometrium , pregnancy , obstetrics , abortion , alternative medicine , pathology , biology , genetics , pharmacology
Objective : To evaluate the efficacy of intrauterine lidocaine plus buccal misoprostol in reducing the discomfort caused by endometrial biopsy with a suction curette. Methods : In this double‐blind, randomized, placebo‐controlled trial 126 women undergoing endometrial biopsy were administered a 200‐μg tablet of misoprostol buccally, followed by a 5‐mL uterine instillation of either of 2% lidocaine or a saline solution. The main outcome measures were the intensity of pain during, immediately following, and 20 min following the biopsy, as assessed on a 10‐cm visual analog scale. Statistical analysis was performed using the Friedman test with the Bonferroni correction, the t test, and the χ 2 test. Results : There were no statistically significant differences between the study and control groups in mean age, parity, or relevant medical history. A statistically significant difference in pain scores was noted in premenopausal women during the procedure (lidocaine, 4.93 ± 1.67; placebo, 6.17 ± 1.26; P < 0.001) as well as immediately later (lidocaine, 4.12 ± 1.14 vs. placebo, 5.42 ± 1.08; P < 0.001) and 20 min later (lidocaine, 3.60 ± 1.10; placebo, 4.22 ± 1.46; P < 0.001). No significant differences in pain scores were observed in postmenopausal women for any of the 3 time points (6.72 ± 2.01, 5.18 ± 1.22, and 4.56 ± 0.80, respectively; P > 0.05). The number needed to treat was 2.6 (95% confidence interval, 1.9–4.8). Conclusion : Intrauterine lidocaine plus buccal misoprostol appears to be effective in decreasing pain in premenopausal women undergoing endometrial biopsy with a suction curette.