Premium
Calcium plus linoleic acid therapy for pregnancy‐induced hypertension
Author(s) -
Herrera J.A.,
Shahabuddin A.K.M.,
Ersheng G.,
Wei Yuan,
Garcia R.G.,
LópezJaramillo P.
Publication year - 2005
Publication title -
international journal of gynecology and obstetrics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.895
H-Index - 97
eISSN - 1879-3479
pISSN - 0020-7292
DOI - 10.1016/j.ijgo.2005.08.018
Subject(s) - medicine , placebo , calcium , incidence (geometry) , pregnancy , confidence interval , endothelial dysfunction , conjugated linoleic acid , endocrinology , linoleic acid , gastroenterology , fatty acid , biochemistry , physics , alternative medicine , pathology , biology , optics , genetics , chemistry
Objective : To determine the effect of dietary supplementation of calcium plus conjugated linoleic acid (calcium–CLA) in reducing the incidence of vascular endothelial dysfunction in pregnant women at high risk of developing pregnancy‐induced hypertension (PIH). Patients and methods : This randomized, double‐blind, placebo‐controlled trial conducted at 4 outpatient clinics in 2 developing countries recruited 48 healthy primigravidas younger than 19 years or older than 35 years who had a family history of pre‐eclampsia and diastolic notch. Twenty‐four participants received daily elemental calcium (600 mg) plus CLA (450 mg) and 24 received placebo from week 18 to 22 of pregnancy until delivery. Results : Calcium–CLA supplementation reduced significantly the incidence of PIH (2 cases [8%] in the study group vs. 10 cases [42%] in the placebo group; relative risk, 0.20; 95% confidence interval, 0.05–0.82; P = .01). Endothelial dysfunction was also significantly reduced after calcium–CLA supplementation (in 18 women [75%] vs. 4 women [17%]; P < .001), compared with the placebo group (in 15 [63%] vs. 9 women [38%]; P = .08). Conclusion : In pregnant women at high risk for PIH, calcium–CLA supplementation decreases the incidence of PIH and improves endothelial function.