Histologic and clinical significance of atypical glandular cells on pap smears | Zendy

Daniel A. | Zendy; Barreth D. | Zendy; Schepansky A. | Zendy; Johnson G. | Zendy; Capstick V. | Zendy; Faught W. | Zendy

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Histologic and clinical significance of atypical glandular cells on pap smears

Author(s) -

Daniel A.,

Barreth D.,

Schepansky A.,

Johnson G.,

Capstick V.,

Faught W.

Publication year - 2005

Publication title -

international journal of gynecology and obstetrics

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.895

H-Index - 97

eISSN - 1879-3479

pISSN - 0020-7292

DOI - 10.1016/j.ijgo.2005.08.009

Subject(s) - medicine , histology , cytology , adenocarcinoma , cervix , pathology , pap smears , bethesda system , gynecology , cancer , cervical cancer

Objective: To determine the association between atypical glandular cells (AGC) on Pap smear and clinically significant histology, in a large health region. Methods: A cytologic database of over one million Pap smears was reviewed for a result of AGUS/AGC. Cytologic and histologic follow up was obtained to establish the presence of significant histology. Results: 456 patients available for follow up had AGUS/AGC cytology results (0.043% of all Pap smear results). 197(45.2%) patients had a clinically significant diagnosis including 40 with adenocarcinoma in situ (AIS) of the cervix and 48 with endometrial cancer. Conclusion: AGC on a Pap smear is frequently associated with a clinically significant diagnosis.

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