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Inflammatory bowel disease and preterm delivery
Author(s) -
Elbaz Gabby,
Fich Alex,
Levy Amalia,
Holcberg Gershon,
Sheiner Eyal
Publication year - 2005
Publication title -
international journal of gynecology and obstetrics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.895
H-Index - 97
eISSN - 1879-3479
pISSN - 0020-7292
DOI - 10.1016/j.ijgo.2005.06.003
Subject(s) - medicine , odds ratio , pregnancy , ulcerative colitis , obstetrics , inflammatory bowel disease , confidence interval , premature birth , case control study , crohn's disease , gestation , apgar score , risk factor , gestational age , disease , genetics , biology
Objective : The present study investigates pregnancy outcome in women with IBD and examines the effect of pregnancy on the severity of IBD. Method : A case‐control study comparing deliveries by mothers with IBD between January 1988 and January 2005 was performed. For every birth by a mother with IBD, four births by non‐IBD mothers were randomly selected and adjusted for ethnicity and year of delivery. Result : During the study period there were 48 deliveries to patients with Crohn's disease and 79 deliveries to patients with ulcerative colitis. Higher rates of preterm delivery (< 37 weeks) were found among patients with IBD as compared to the controls (odds ratios (OR) = 2.2; 95% confidence interval (CI) = 1.3–3.8). This association remained significant after adjustment for labor induction and multiple gestations, using the Mantel–Haenszel technique (weighted OR = 2.1; 95% CI 1.3–3.5 and weighted OR = 2.0; 95% CI 1.2–3.5; P = 0.012; respectively). In addition, these patients had higher rates of fertility treatments (OR = 2.2; 95% CI = 1.1–4.4). Using a multivariate analysis, controlling for maternal age and fertility treatments, preterm delivery was seen to be significantly associated with IBD (adjusted OR = 2.0; 95% CI = 1.2–3.5). Perinatal outcomes, such as perinatal mortality, low Apgar scores, and congenital malformations, were comparable to the outcomes in the control group. Conclusion : Maternal IBD is an independent risk factor for preterm delivery. IBD is not associated with adverse perinatal outcome.