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Large loop excision and cold coagulation for management of cervical intraepithelial neoplasia
Author(s) -
Allam M.,
Paterson A.,
Thomson A.,
Ray B.,
Rajagopalan C.,
Sarkar G.
Publication year - 2005
Publication title -
international journal of gynecology and obstetrics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.895
H-Index - 97
eISSN - 1879-3479
pISSN - 0020-7292
DOI - 10.1016/j.ijgo.2004.09.019
Subject(s) - medicine , cervical intraepithelial neoplasia , cytology , surgery , randomized controlled trial , retrospective cohort study , cohort , colposcopy , cervical cancer , cancer , pathology
Objectives: To evaluate the efficacy of large loop excision of the transformation zone (LLETZ) combined with a single application of the cone probe of a Semm Cold Coagulator as a new treatment for women with cervical intraepithelial neoplasia (CIN). Methods: Retrospective case‐record review of 666 women treated with large loop excision and cold coagulation (LLECC) from 1992 to 2000. Results: Of the women who had high‐grade CIN at their initial consultation, 4.2% had abnormal cytologic results 6 months after treatment and 0.6% had abnormal cytologic results at 12 months. Of the women who had low‐grade CIN at initial presentation, 3.8% had abnormal cytologic results 6 months after treatment and none (0%) at 12 months. Furthermore, there were no reported cases of cervical cancer in this cohort of women during the follow‐up period. Short‐term bleeding complications (within 24 h of the procedure) occurred in 1% of the women assessed. Conclusions: Large loop excision combined with cold coagulation is a new and effective treatment for CIN. Randomized controlled trials are required to confirm these findings and determine the long‐term safety of the technique.