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Tumor necrosis factor receptor 1 expression and early spontaneous abortion
Author(s) -
Yu X.W.,
Yan C.F.,
Jin H.,
Li X.
Publication year - 2005
Publication title -
international journal of gynecology and obstetrics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.895
H-Index - 97
eISSN - 1879-3479
pISSN - 0020-7292
DOI - 10.1016/j.ijgo.2004.08.020
Subject(s) - medicine , decidua , stromal cell , flow cytometry , decidual cells , tumor necrosis factor alpha , andrology , pregnancy , immunohistochemistry , receptor , exact test , tumor necrosis factor receptor 1 , endocrinology , placenta , immunology , fetus , biology , tumor necrosis factor receptor , genetics
Objectives To compare tumor necrosis factor receptor 1 (TNFR1) protein expression in women with unexplained early spontaneous abortion (UESA) and normal pregnancy. Methods In a prospective study, 62 women with UESA and 60 with normal pregnancy were studied. Decidual membrane TNFR1 was detected by flow cytometry and immunohistochemistry, and serum soluble TNFR1 were by ELISA. Statistical analyses of resulting data employed the student's t test, the Fisher's Exact, and the nonparametric Wilcoxon test Results The percentage of membrane tumor necrosis factor receptor 1 (mTNFR1) positive decidual cells was 16.42±7.1 for women with UESA and 12.47±5.3 for women with normal pregnancy ( p <0.05). The number of mTNFR1 positive cells was more in decidual stromal and vessel endothelial cells in women with UESA, and serum soluble tumor necrosis factor receptor 1 (sTNFR1) concentration was significantly higher than in women with normal pregnancy (554.56±126.7 pg/ml vs. 175.3±52.4 pg/ml; p <0.001). Conclusion The overexpression of TNFR1 may contribute to the development of ESA.