Premium
Beta‐human chorionic gonadotropin in cervicovaginal secretions and preterm delivery
Author(s) -
Garshasbi A.,
Ghazanfari T.,
Faghih Zadeh S.
Publication year - 2004
Publication title -
international journal of gynecology and obstetrics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.895
H-Index - 97
eISSN - 1879-3479
pISSN - 0020-7292
DOI - 10.1016/j.ijgo.2004.05.006
Subject(s) - medicine , gestation , gynecology , human chorionic gonadotropin , obstetrics , odds ratio , asymptomatic , pregnancy , vagina , preterm delivery , surgery , hormone , biology , genetics
Objectives : To determine whether concentrations of β‐HCG in cervicovaginal secretions could predict spontaneous preterm birth (SPB) in asymptomatic high risk pregnancies. Methods : A cohort study was undertaken with cervicovaginal samples collected from 540 pregnant women between 20 to 28 weeks of gestation. Levels of β‐HCG were measured by ELISA test. Results : There was 3.2‐fold increase in cervicovaginal β‐HCG concentrations among patients with SPB vs. term delivery. A single cervicovaginal β‐HCG >77.8mIU/ml, between 20 and 28 weeks’ gestation, identified patients with subsequent SPB vs. term delivery with sensitivity of 87.5% (95% CI: 47.4–97.9) and a specificity of 97% (95% CI: 86.5–99.4) with positive and negative predictive values of 88.5% and 98%, respectively. Multiple logistic regression indicates that cervicovaginal β‐HCG level >77.8mIU/ml was an independent predictor of SPB (adjusted odds ratio 19.97, 95% CI: 10.65–37.45). Conclusions : Cervicovaginal β‐HCG is a sensitive and specific predictor of patients with subsequent preterm delivery.