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Endometrial thickness after misoprostol use for early pregnancy failure
Author(s) -
Creinin M.D,
Harwood B,
Guido R.S,
Fox M.C,
Zhang J
Publication year - 2004
Publication title -
international journal of gynecology and obstetrics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.895
H-Index - 97
eISSN - 1879-3479
pISSN - 0020-7292
DOI - 10.1016/j.ijgo.2004.02.004
Subject(s) - medicine , misoprostol , obstetrics , pregnancy , gestation , gestational sac , gestational age , products of conception , vacuum aspiration , gynecology , abortion , population , family planning , research methodology , genetics , environmental health , biology
Objectives : To assess if there was any potential relationship between endometrial thickness and final treatment outcome in women successfully treated with misoprostol for a first trimester anembryonic gestation, embryonic demise or fetal demise. Methods : Eighty women were treated with up to two doses of misoprostol 800 μg vaginally for early pregnancy failure. Subjects were scheduled to return 2 (range 1–4), 7 (range 5–9) and 14 (range 12–17) days after treatment. Transvaginal ultrasonography was performed at each follow‐up visit. Results : The median endometrial thickness at each of the follow‐up visits for women who had expelled the gestational sac was 14 mm, 10 mm, and 7 mm, respectively. The endometrial thickness at the first follow‐up visit exceeded 15 mm in 20 subjects (36%) and 30 mm in four subjects (7%). Only three women had a suction aspiration for bleeding after documented expulsion. The endometrial thickness for these women was 11, 13, and 14 mm at the first follow‐up visit. Conclusions : There is no obvious relationship between increasing endometrial thickness and the need for surgical intervention in women treated with misoprostol for early pregnancy failure.