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Human papillomavirus infection and cervical ectopy
Author(s) -
RochaZavaleta L.,
Yescas G.,
Cruz R.M.,
CruzTalonia F.
Publication year - 2004
Publication title -
international journal of gynecology and obstetrics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.895
H-Index - 97
eISSN - 1879-3479
pISSN - 0020-7292
DOI - 10.1016/j.ijgo.2003.10.002
Subject(s) - medicine , human papillomavirus , virology
Objectives : To investigate the prevalence of human papillomavirus (HPV), and HPV type 16 (HPV16) infection in cervical ectopy, and the presence of anti‐HPV16 secretory IgA (sIgA) antibodies. Methods : DNA from patients with cervical ectopy ( n =218), HPV‐associated lesions ( n =111), and controls without evidence of cervical ectopy or HPV infection ( n =93) were analyzed by PCR for the presence of HPV and HPV16. The presence of mucosal sIgA antibodies against HPV16 capsid antigens (VLP) was assayed in cervical mucus by ELISA. Results : Prevalence of HPV DNA was higher in cervical ectopy than in controls ( P =0.04; OR=2.06; 95% CI 0.99–4.33). HPV16 was 6.3 times more prevalent in cervical ectopy than in controls. Anti‐HPV16 sIgA were detected more frequently in cervical ectopy patients than in controls ( P =0.0004). Conclusions : Cervical ectopy correlates with HPV infection. HPV16 is highly prevalent in cervical ectopy. sIgA antibodies against HPV16 capsids are generated in patients with cervical ectopy.