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The brain's kryptonite: Overview of punctate white matter lesions in neonates
Author(s) -
Nguyen Annie L.A.,
Ding Yang,
Suffren Sabrina,
Londono Irène,
Luck David,
Lodygensky Gregory A.
Publication year - 2019
Publication title -
international journal of developmental neuroscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.761
H-Index - 88
eISSN - 1873-474X
pISSN - 0736-5748
DOI - 10.1016/j.ijdevneu.2019.04.006
Subject(s) - white matter , etiology , medicine , narrative review , hyperintensity , pathology , pediatrics , magnetic resonance imaging , intensive care medicine , radiology
With increasing advances in the field of medical brain imaging, the known spectrum of white matter lesions has expanded, and we can now assess the presence of punctate white matter lesions (PWML). These focal small lesions are quite frequently detected in the preterm infant and in full‐term infants with congenital heart malformations with, some studies reporting a link between these lesions and adverse long‐term outcomes. The etiology of PWML has sparked a lot of questions over the years, some of which still remain unanswered. This narrative review will bring an overview of current knowledge and their significant clinical importance in the newborn brain.