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Expression of the long non‐coding RNA H19 and MALAT‐1 in growth hormone‐secreting pituitary adenomas and its relationship to tumor behavior
Author(s) -
Lu Tianyu,
Yu Chen,
Ni Hongbin,
Liang Weibang,
Yan Huiying,
Jin Wei
Publication year - 2018
Publication title -
international journal of developmental neuroscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.761
H-Index - 88
eISSN - 1873-474X
pISSN - 0736-5748
DOI - 10.1016/j.ijdevneu.2018.03.009
Subject(s) - acromegaly , long non coding rna , hormone , biology , meg3 , cancer research , growth hormone , medicine , bioinformatics , endocrinology , rna , gene , genetics
Abstract Aggressive growth hormone‐secreting pituitary adenomas (GHPAs) represent an important clinical problem in patients with acromegaly. Surgical therapy, although often the mainstay of treatment for GHPAs, is less effective in aggressive GHPAs due to their invasive and destructive growth patterns, and their proclivity for infrasellar invasion. LncRNAs are important players in cancer development and emerging in various fundamental biological processes. In the present study, qRT‐PCR was performed to examine the expression of lncRNA H19 and MALAT‐1 in invasive and non‐invasive GHPAs. Our results revealed that the expression of lncRNA H19 was remarkably higher in invasive GHPAs, however, there was no significant differences between the expression of lncRNA MALAT‐1 in invasive GHPAs and non‐invasive GHPAs, suggesting that lncRNA H19 may play an important role in GHPA invasion. LncRNA H19 might be a target for the study of GHPAs invasion, and a potential index for the diagnosis or prognosis of GHPAs.