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Schneiderian first rank symptoms in schizophrenia: A developmental neuroscience evaluation
Author(s) -
Tikka Sai Krishna,
Nizamie S.Haque,
Das Archana Kumari,
Agarwal Nidhi,
Goyal Nishant
Publication year - 2016
Publication title -
international journal of developmental neuroscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.761
H-Index - 88
eISSN - 1873-474X
pISSN - 0736-5748
DOI - 10.1016/j.ijdevneu.2016.02.001
Subject(s) - psychology , schizophrenia (object oriented programming) , neurochemical , neuropsychology , psychopathology , neuroscience , resting state fmri , audiology , clinical psychology , psychiatry , medicine , cognition
Self disorders in schizophrenia have been suggested to have distinct neurobiological underpinnings. Using comprehensive neuro‐scientific assessments including a neurophysiological, a neurochemical and a neuropsychological marker, this study assesses disordered‐“self” in schizophrenia. Methods Twenty schizophrenia patients with first rank symptoms (FRS;FRS+), 20 patients without FRS (FRS−) and 20 healthy controls (HC) were assessed for psychopathology, especially on specially designed FRS score sheets with a narrow and a broad definition. Resting state electroencephalography was acquired using 256‐electrodes; gamma spectral‐power was measured in 8 regions of interest. Serum BDNF and self‐monitoring were also assessed. Comparative and correlation analysis were conducted in addition to a step‐wise discriminant function analysis. Results FRS+ group with greater positive symptom score and a lower negative symptom score, showed significantly increased gamma spectral power, especially on right hemispheric regions, along with lower BDNF levels and lower scores on self‐monitoring compared to FRS− and HC. Serum BDNF levels and gamma spectral power in the region corresponding right inferior parietal lobule were identified as predictors that most accurately classified the defined groups. Conclusions Schizophrenia patients satisfying the criteria of presence of first rank symptoms represent a distinct neurodevelopmental subgroup with associated features of predominantly positive symptoms, significantly lower neurotrophin levels, aberrant resting state brain activity in the heteromodal association cortex and performing poorer on self‐monitoring tasks.