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ISDN2014_0430: Layer‐specific development of receptive field properties and network synchrony in mouse visual cortex
Author(s) -
Hoy J.L.,
Niell C.M.
Publication year - 2015
Publication title -
international journal of developmental neuroscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.761
H-Index - 88
eISSN - 1873-474X
pISSN - 0736-5748
DOI - 10.1016/j.ijdevneu.2015.04.345
Subject(s) - citation , library science , neuroscience , cognitive science , computer science , psychology
The laminar structure and conserved cellular organization of mouse visual cortex provide a useful model to determine the mechanisms that support the development of basic visual system function. However, the normal development of many receptive field properties, as well as the emergence of synchronized network activity, have not yet been thoroughly quantified as a function of cortical layer. Here, we employ multisite electrophysiological recording in the awake mouse across an extended period of development, starting at eye opening, to measure these functional properties in V1. Consistent with previous work, we find that several receptive field properties change rapidly over the first few days after eye-opening, followed by much slower refinement up through one month of age. For example, orientation selectivity increases in layers 2 through 5 most dramatically within the first 3 days of eye opening, but does not fully mature until one month of age. In contrast, other response features such as spatial frequency preference and direction selectivity are immature at eye opening, but reach adult-like states within the first three days of eye opening without further refinement. We found evidence for layer specific developmental changes as well as changes that were common to every layer. In particular, direction selectivity undergoes significant developmental change only in layer 4. In contrast, the developmental increase in the number of neurons that respond to high spatial frequency drifting gratings (>= 0.16 cpd) was noted in every layer and reached maturity in each layer at the same time point, 3 days after eye opening. Behavioural state modulation of LFP gamma power also changes significantly over development in a layer specific manner. Similar to orientation selectivity, LFP oscillations mature most rapidly within the first three days of eye opening, but continue to develop until one month of age. On-going studies seek to determine the cell type-specific molecular mechanisms that drive these changes.