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ISDN2014_0352: Effects of prenatal alcohol exposure on social interaction in early and late adolescent male and female rats
Author(s) -
Holman P.J.,
Hill L.A.,
Wind K.,
Haghighat S.,
Mukhi N.,
Takeuchi L.,
Hammond G.L.,
Weinberg J.
Publication year - 2015
Publication title -
international journal of developmental neuroscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.761
H-Index - 88
eISSN - 1873-474X
pISSN - 0736-5748
DOI - 10.1016/j.ijdevneu.2015.04.291
Subject(s) - columbia university , library science , gerontology , medicine , history , sociology , media studies , computer science
hypoxia decreases expression of synaptic proteins i.e. synaptophysin, PSD-95and synapsin which further validated by western blotting whereas exposing them in enriched environment ameliorate this synaptic loss. Golgi staining reveals protective effect of enriched environment during HH exposure as evident from increased dendritic arborisation, spine density and morphology. Present study also reveals the role of BDNF/TrkB signalling in EE mediated modulation hippocampal synaptic palsitcity.