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ISDN2014_0317: Auditory cortical structure predicts superior pitch processing in children with autism
Author(s) -
Foster Nicholas,
Tryfon Ana,
Ouimet Tia,
DoyleThomas Krissy,
Anagnostou Evdokia,
Evans Alan,
Zwaigenbaum Lonnie,
Hyde Krista
Publication year - 2015
Publication title -
international journal of developmental neuroscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.761
H-Index - 88
eISSN - 1873-474X
pISSN - 0736-5748
DOI - 10.1016/j.ijdevneu.2015.04.264
Subject(s) - montreal cognitive assessment , library science , psychology , media studies , sociology , cognitive impairment , psychiatry , cognition , computer science
indicated a reappearance of the myelinated cortical fibers. However, these new fibers lacked directionality observed in the control brains. The analysis of Ki67 antigen, known to be associated with proliferating cells, showed increased number of proliferating cells in the subventricular Zone (SVZ) of the STB mice which followed by a reduction in the LTB mice. We observed blast-induced migration of immature Olig2 expressing oligodendrocytes through the corpus callosum and increased number of Olig2+ cells in the cingulate cortex of LTB mice. Immunostaining for an early neuronal cell marker, Doublecortin, suggests a transient blast-induced increase in the number of neuronal progenitors in the SVZ. The results suggest that the increase in blast-induced activation of the brain neural stem/progenitor cells generates predominantly new oligodendrocytes. This work was supported by NYSTEM contracts C026415 and C026714.