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ISDN2014_0249: Corticosteroid receptor immunoreactivity in neurons of the hippocampus, amygdala and paraventricular nucleus, in rats under maternal separation and chronic stress: Effects of tianeptine
Author(s) -
Verónica Trujillo,
Angélica Rivarola María,
Patricia Durando,
Marta Suárez
Publication year - 2015
Publication title -
international journal of developmental neuroscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.761
H-Index - 88
eISSN - 1873-474X
pISSN - 0736-5748
DOI - 10.1016/j.ijdevneu.2015.04.204
Subject(s) - amygdala , hippocampus , neuroscience , medicine , psychology , humanities , art
The investigation was carried out to evaluate alterations in histoarchitecture, oxidative stress parameter (lipid peroxidation, LPx) and antioxidant enzyme activities in cerebral cortex of rat brain in response to 6-n-propyl 2-thiouracil (PTU)-induced hypothyroidism during postnatal development (from birth to 7, 15 and 30 days old). Hypothyroidism in rats was induced by feeding the lactating mothers (from the day of parturition till weaning, 25 days old) or directly to the pups with 0.05% PTU in drinking water. A significant decrease in level of LPx was seen in 7 and 30 days old PTU-treated rats with respect to their controls. Significantly decreased activities of superoxide dismutase (SOD) and catalase (CAT) along with the translated products of SOD1 and SOD2 were observed in 7, 15 and 30 days old PTU-treated rats as compared to their respective controls. However, increase in translated product of CAT was seen in all age groups of PTU-treated rats. Histological sections of 30 days hypothyroid rats clearly exhibited a decline in neuronal migration with neurons packed together in the hypothyroid group as compared to the control. These results suggest that deprivation of thyroid hormone modulates antioxidant defence status as well as the histoarchitecture of rat brain cerebral cortex during postnatal development.