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ISDN2014_0226: Antisaccade saccadic reaction time after completion of videogame training program for individuals with autism spectrum disorder
Author(s) -
Hall Layla,
Kelley Elizabeth,
Wilson Daryl,
Rajsic Jason,
Ladwig Elena,
Furlano Rosaria
Publication year - 2015
Publication title -
international journal of developmental neuroscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.761
H-Index - 88
eISSN - 1873-474X
pISSN - 0736-5748
DOI - 10.1016/j.ijdevneu.2015.04.188
Subject(s) - queen (butterfly) , art history , psychology , history , biology , hymenoptera , botany
no drug, fluoxetine, or D-serine in combination with either normal vision or 1 week of monocular deprivation. We used Western blotting to quantify expression of the glutamate receptor anchoring protein PSD-95, and GABAA receptor anchoring protein Gephyrin. We determined the PSD-95 to Gephyrin balance because their interactions regulate the number of E–I synapses and physiological E–I balance. We found that monocular deprivation alone caused a large shift towards excitation. While neither drug altered the E–I balance both drugs affected the shift driven by monocular deprivation. Fluoxetine decreased the magnitude of E–I shift and D-serine reversed it completely in favor of inhibition. Together, the results show that critical period-like plasticity reinstated by fluoxetine or D-serine in adult visual cortex uses different synaptic mechanisms to alter the experience-dependent E–I balance.