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ISDN2014_0209: Outcomes in children with cerebral palsy: Does the level of neonatal care make a difference? Evidence from population based Cerebral Palsy registry
Author(s) -
Bolbocean Corneliu,
Shevell Michael,
Oskoui Maryam
Publication year - 2015
Publication title -
international journal of developmental neuroscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.761
H-Index - 88
eISSN - 1873-474X
pISSN - 0736-5748
DOI - 10.1016/j.ijdevneu.2015.04.173
Subject(s) - cerebral palsy , citation , population , medicine , library science , psychology , pediatrics , demography , sociology , computer science , physical therapy
fewer efforts have been dedicated towards understanding outcomes in developing populations. The aim of this study was to investigate the influence of concussion history on children’s neurocognitive performance. Thirty children age 8-10 years (15 controls, 15 concussion; m = 2.1 years from injury) were matched based on the demographic factors of age, sex, SES, IQ, pubertal timing, ADHD symptoms, cardiorespiratory fitness and social support for academics. Children completed an N-back task, as well as GoNogo task, which afforded the measurement of event-related brain potentials (ERPs). Relative to children without a history of concussion (controls), children with a history of concussion exhibited several behavioral and neuroelectric differences. Specifically, relative to controls, children with a history of concussion exhibited decreased accuracy during the N-back task; however, this overall difference was punctuated by a selective group difference in d’ scores for the 2-back condition of the task. Children with a history of concussion also committed more false alarms during the Nogo condition of the Go-Nogo task. Together, these results highlight the potential specificity of cognitive deficits stemming from pediatric concussion when extensive amounts of cognitive control are required. On the neural level, children with a history of concussion exhibited multiple alterations including decreased N1 amplitude, prolonged N2 latency and decreased P3 amplitude across both conditions of the Go-Nogo task. Pediatric concussion therefore appears to lead to a multitude of neural alterations indicative of deficits in perceptual processing, conflict resolution, and attentional resource allocation. Collectively, the current results indicate that a single concussive incident may negatively influence the development of attention and cognitive control processes and their neural progenitors. These results will serve to inform a growing public health concern in a poorly understood population.