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ISDN2014_0117: Brain morphometry of Dravet Syndrome
Author(s) -
Pérez A.,
GarcíaPentón L.,
CanalesRodríguez E.J.,
LermaUsabiaga G.,
Davidson D.,
AlemánGómez Y.,
IturriaMedina Y.,
Acha J.,
Carreiras M.
Publication year - 2015
Publication title -
international journal of developmental neuroscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.761
H-Index - 88
eISSN - 1873-474X
pISSN - 0736-5748
DOI - 10.1016/j.ijdevneu.2015.04.096
Subject(s) - humanities , center (category theory) , cognition , dravet syndrome , psychology , neuroscience , philosophy , epilepsy , chemistry , crystallography
Summary The aim of this study was to identify differential global and local brain structuralpatterns in Dravet Syndrome (DS) patients as compared with a control subject group, usingbrain morphometrytechniqueswhichprovideaquantitativewhole-brainstructuralanalysisthatallows for specic patterns to be generalized across series of individuals. Nine patients withthe diagnosis of DS that tested positive for mutation in the SCN1A gene and nine well-matchedhealthy controls were investigated using voxel brain morphometry (VBM), cortical thicknessand cortical gyrication measurements. Global volume reductions of gray matter (GM) andwhite matter (WM) were related to DS. Local volume reductions corresponding to several whitematter regions in brainstem, cerebellum, corpus callosum, corticospinal tracts and associationbers (left inferior fronto-occipital fasciculus and left uncinate fasciculus) were also found.Furthermore, DS showed a reduced cortical folding in the right precentral gyrus. The presentndings describe DS-related brain structure abnormalities probably linked to the expression ofthe SCN1A mutation.© 2014 Elsevier B.V. All rights reserved.