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Epigenetic regulation of neural stem cell fate during corticogenesis
Author(s) -
MuhChyi Chai,
Juliandi Berry,
Matsuda Taito,
Nakashima Kinichi
Publication year - 2013
Publication title -
international journal of developmental neuroscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.761
H-Index - 88
eISSN - 1873-474X
pISSN - 0736-5748
DOI - 10.1016/j.ijdevneu.2013.02.006
Subject(s) - corticogenesis , neurogenesis , gliogenesis , neuroscience , neural stem cell , biology , progenitor cell , epigenetics , progenitor , cerebral cortex , neural development , cell fate determination , stem cell , microbiology and biotechnology , genetics , gene , transcription factor
The cerebral cortex comprises over three quarters of the brain, and serves as structural basis for the sophisticated perceptual and cognitive functions. It develops from common multipotent neural stem cells (NSCs) that line the neural tube. Development of the NSCs encompasses sequential phases of progenitor expansion, neurogenesis, and gliogenesis along with the progression of developmental stages. Interestingly, NSCs steadfastly march through all of these phases and give rise to specific neural cell types in a temporally defined and highly predictable manner. Herein, we delineate the intrinsic and extrinsic factors that dictate the progression and tempo of NSC differentiation during cerebral cortex development, and how epigenetic modifications contribute to the dynamic properties of NSCs.