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Epigenetic mechanisms regulating learning and long‐term memory
Author(s) -
Lipsky Robert H.
Publication year - 2013
Publication title -
international journal of developmental neuroscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.761
H-Index - 88
eISSN - 1873-474X
pISSN - 0736-5748
DOI - 10.1016/j.ijdevneu.2012.10.110
Subject(s) - neuroscience , neurodegeneration , epigenetics , synaptic plasticity , cognition , neuroplasticity , cognitive decline , psychology , disease , balance (ability) , biology , medicine , dementia , receptor , pathology , gene , biochemistry
A balance between rapid, short lived, neuronal responses and prolonged ones fulfill the biochemical and cellular requirements for creating a molecular memory. I provide an overview of epigenetic mechanisms in the brain and discuss their impact on synaptic plasticity, cognitive functions, and discuss a recent example of how they can contribute to neurodegeneration and the cognitive decline associated with Alzheimer's disease.