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ISDN2012_0280: FGF8 specifies areas throughout the neocortex and controls the topography of sensory maps within areas
Author(s) -
Assimacopoulos Stavroula,
Kao Tina,
Issa Naoum P.,
Grove Elizabeth A.
Publication year - 2012
Publication title -
international journal of developmental neuroscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.761
H-Index - 88
eISSN - 1873-474X
pISSN - 0736-5748
DOI - 10.1016/j.ijdevneu.2012.10.101
Subject(s) - library science , gerontology , psychology , neuroscience , medicine , computer science
neurogenesis, through the identification of novel genes involved in this process. Moreover, it constitutes a unique model linking cortical development and evolution, as the mouse and human pathways of corticogenesis display many similarities but also striking differences that may be related to species-specific developmental programmes. Finally, when grafted into the cerebral cortex of newborn mice, or lesioned cortex of adult mice, mouse and human ESC-derived cortical neurons develop complex and specific patterns of axonal and dendritic projections corresponding to endogenous cortical projections in vivo.