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ISDN2012_0267: Regional neural tube closure defined by the Grainy head ‐like transcription factors
Author(s) -
Boglev Yeliz,
Dworkin Sebastian,
Wilanowski Tomasz,
Caddy Jacinta,
Cangkrama Michael,
Auden Alana,
Ting Stephen B.,
Jane Stephen M.
Publication year - 2012
Publication title -
international journal of developmental neuroscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.761
H-Index - 88
eISSN - 1873-474X
pISSN - 0736-5748
DOI - 10.1016/j.ijdevneu.2012.10.089
Subject(s) - university hospital , clinical practice , medicine , emergency medicine , family medicine
neuron. Specifically, I will show that the plane of cell division is non-random in GCPs, that asymmetric segregation of -catenin and N-cadherin is correlated with increased progenitor cell differentiation with increasing age and finally that the instance of asymmetric segregation of proteins can be changed by manipulating the level of Sonic hedgehog signaling, a major mitogen for GCP proliferation.
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