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ISDN2012_0261: Wiring thalamocortical connectivity: From axon guidance to plasticity
Author(s) -
Gezelius Henrik,
LópezBendito Guillermina
Publication year - 2012
Publication title -
international journal of developmental neuroscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.761
H-Index - 88
eISSN - 1873-474X
pISSN - 0736-5748
DOI - 10.1016/j.ijdevneu.2012.10.084
Subject(s) - medicine , humanities , library science , art , computer science
astrocytic tunnels. Through the neuron-glia interaction mediated by Slit1-Robo signaling, these new neurons regulate the formation of the astrocytic meshwork that is needed to enable their rapid and directional migration in adult brain. In the adult common marmoset, a New World primate used widely in neuroscience, the SVZ contains cells similar to stem and progenitor cells of the rodent SVZ in their marker expression and morphology, and has a three-layer organization similar to the adult human SVZ. The marmoset SVZ also contains chain-like aggregates of new migrating neurons surrounded by astrocytes. However, the RMS becomes thinner as it approached the OB, suggesting that these cells do not travel efficiently to the OB, much as in humans. Adult zebrafish also contains RMS in which new neurons migrate towards the OB. Unlike the mammalian RMS, these new neurons are not surrounded by glial tubes, although radial glial cells lined the ventricular wall, similar to embryonic and neonatal mammals. The neural stem cells in the adult SVZ also have the capacity to partially regenerate new neurons after various insults. After ischemic injury in rodents, the SVZ-derived new neurons migrate from the SVZ towards the injured site along blood vessels. In this talk, I will summarize these mechanisms of neuronal migration occurring in the adult brain of various animals under physiological and pathological conditions.