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ISDN2012_0243: Modeling the maternal infection risk factor for schizophrenia and autism in mice
Author(s) -
Patterson Paul H.
Publication year - 2012
Publication title -
international journal of developmental neuroscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.761
H-Index - 88
eISSN - 1873-474X
pISSN - 0736-5748
DOI - 10.1016/j.ijdevneu.2012.10.072
Subject(s) - citation , schizophrenia (object oriented programming) , autism , library science , associate editor , psychoanalysis , psychology , psychiatry , cognitive science , computer science
Several types of maternal infection (influenza, rubella, genital and reproductive system viruses, bacteria) are associated with increased risk of schizophrenia or autism in the offspring. Modeling this risk factor in mice using influenza infection or activation of the dam's immune system by injection of the double stranded, synthetic RNA, poly(I:C) yields offspring with characteristic features of these disorders. These include behaviors (enhanced anxiety and stereotyped/compulsive behaviors, and deficits in social interaction, communication, prepulse inhibition, latent inhibition, learning) and neuropathology (parvalbumin and Purkinje cell deficits, enlarged ventricles). The cytokine IL-6 is a key mediator of the effects of poly(I:C)-induced maternal immune activation (MIA) on the fetus, as shown by blocking or genetically inactivating IL-6 in the MIA dam. Moreover, MIA activates downstream IL-6 signaling pathways in the placenta, leading to important changes in placental immune cells and endocrine functions. In addition, IL-6 and several other cytokines are induced in both the placenta and fetal brain. Consistent with reports of alterations in the immune system in schizophrenia and autism, we find that MIA leads to significant changes in lymphocytes from the spleen and mesenteric lymph node of adult offspring. As is the case a subset of autistic children, MIA offspring also exhibit gastrointestinal pathology. Thus, the MIA model has face and construct validity for schizophrenia and autism, and is proving useful for exploring the mechanism of how the maternal infection risk factor alters fetal brain and immune system development.