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ISDN2012_0293: Neurobehavioral changes in different stages of fluorosis and its correlation with acetylcholinesterase activity: A clinical study in Jaipur district Rajasthan
Author(s) -
Singh Vivek Pratap,
Tripathi Sandeep,
Satapathy Mantosh Kumar,
Kumar Sandeep,
Chauhan Dushyant Singh,
Mishra Sudhanshu,
Seth A.K.
Publication year - 2012
Publication title -
international journal of developmental neuroscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.761
H-Index - 88
eISSN - 1873-474X
pISSN - 0736-5748
DOI - 10.1016/j.ijdevneu.2012.10.063
Subject(s) - library science , computer science
Vivek Pratap Singh 1,∗, Sandeep Tripathi 1, Mantosh Kumar Satapathy 1, Sandeep Kumar 1, Dushyant Singh Chauhan 1, Sudhanshu Mishra 1, A.K. Seth 2 1 Department of Biotechnology, Institute of Advance Science & Technology, India 2 Department of Psychiatry, NIMS Medical College, NIMS University, Jaipur, Rajasthan 303121, India E-mail address: sandeeptripathiphd@gmail.com (V.P. Singh). The prolonged exposure of fluoride (F) can accumulate in the body and it may cause significant damage to health like dental and skeletal fluorosis. Several clinical and experimental studies have reported that the F induces changes in cerebral morphology and biochemistry that affect the neurological development of individuals as well as cognitive processes, such as learning and memory. In the present study we evaluated the prevalence of dental and skeletal fluorosis among adult (age 20–40 years) of Jaipur district, where the fluoride concentration in drinking water ranges from 1.6 to 18.8 ppm. In the present study, 138 patients were recruited for the study. These patients were investigated clinically and biochemically. The study revealed that 72% of the patients had dental fluorosis and 49% exhibited skeletal fluorosis. The age matched controls were collected from the Jaipur district where fluoride concentration were < 1.5 ppm. After the confirmation of flurosis, mini mental exam were conducted thereafter blood samples were collected. The acetylcholinesterase (AChE), lipid peroxide (LPx) and antioxidant levels, i.e., superoxide dismutase, catalase and glutathione levels were estimated. Patients with fluorosis exhibited increased LPx and AChE activity. The linear correlation demonstrate that AChE and MMSE score were parallel when compared with the age matched controls. On the basis of results it may conclude that flurosis causes mental deterioration by the elevation of AChE activity. Other factors like increased lipid peroxidation and depleted antioxidant levels in patients with suffering from flurosis may recommend antioxidant supplements.