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ISDN2012_0232: Molecular mechanisms of somatosensory cortex patterning during development
Author(s) -
Pouchelon Gabrielle,
Golding Bruno,
Jabaudon Denis
Publication year - 2012
Publication title -
international journal of developmental neuroscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.761
H-Index - 88
eISSN - 1873-474X
pISSN - 0736-5748
DOI - 10.1016/j.ijdevneu.2012.10.044
Subject(s) - library science , neurology , psychology , clinical neurology , neuroscience , cognitive science , medicine , humanities , computer science , art
Institut de Physiologie et Biologie Cellulaires, CNRS UMR 6187, Université de Poitiers, France The SubVentricular Zone (SVZ) and the Dentate Gyrus of the Hippocampus are the two main proliferative niches in adult mammalian brain. In the rodent adult brain, neuroblasts generated in the SVZ migrate along the rostral migratory stream (RMS) to the olfactory bulb. Previous studies have demonstrated that in several diseases and in brain injury, newly generated neuroblasts from the SVZ can migrate ectopically to the affected areas, which might constitute an endogenous repair mechanism. The aim of our study is to investigate changes happen in the SVZ following aspiration lesion in the motor cortex of adult mice and to study the ectopic migration of neuroblasts from the SVZ and their fate. We have observed that there is a transient increase in the cellular proliferation in the SVZ, which peaks at day 7, following lesion. Neuroblasts start to migrate out of the RMS to the lesion site after 3 days. This migration appears to be multimodal as we found migrating cells in close association with either blood vessels or glial cells. Some cells also migrate without any such association. We have not observed any ‘chain’ formation; a hallmark of neuroblasts migration along the RMS. This ectopic migration is possibly regulated by SDF1-CXCR4 signaling. The morphology of the glial tube, which restricts neuroblasts within the RMS, is altered and appeared to be more ‘open’ following lesion. Ongoing study is focused on detail characterization of the cell types those are generated following lesion and migrated to the affected area.