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ISDN2012_0206: Compartmentalisation of cerebral cortical germinal zones in a lissencephalic primate and gyrencephalic rodent
Author(s) -
GarciaMoreno Fernando,
Vasistha Navneet A.,
Trevia ata,
Bourne James,
Molnár Zoltán
Publication year - 2012
Publication title -
international journal of developmental neuroscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.761
H-Index - 88
eISSN - 1873-474X
pISSN - 0736-5748
DOI - 10.1016/j.ijdevneu.2012.10.030
Subject(s) - garcia , biology , humanities , anatomy , art
Male Wistar rats were separated from their mother 4.5 hours daily during the first 3 weeks of life. Offspring were weaned on day 21 and housed in same-rearing groups under either standard or enriched conditions. At 60 d of age, all animals were then housed in same-treatment groups, two per cage until testing began on day 74. Emotional and cognitive responses were examined using the open field, novel object recognition test and step down passive avoidance learning. In dorsal hippocampus glucocorticoid receptor (GR) expression and neuronal activity was examined by immunoreactivity. We found that early maternal separation as well as environmental enrichment has independent effect on behavior and hippocampus physiology. There were also interactions between the two postnatal manipulations: some responses affected by MS were reversed by environmental enrichment, but others were not affected or even driven in the same sense. These results provide evidence for the “Match or mismatch” theory of environment during early and later life suggesting that later-life context matters to disentangle the adaptive and maladaptive impact of early adversity.