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Hypothyroxinemia during pregnancy: the effect on neurodevelopment in the child
Author(s) -
SuárezRodríguez Marta,
AzconaSan Julián Cristina,
Alzina de Aguilar Valentín
Publication year - 2012
Publication title -
international journal of developmental neuroscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.761
H-Index - 88
eISSN - 1873-474X
pISSN - 0736-5748
DOI - 10.1016/j.ijdevneu.2012.07.004
Subject(s) - pregnancy , offspring , context (archaeology) , psychomotor learning , medicine , gestation , cognition , endocrinology , psychology , developmental psychology , biology , psychiatry , paleontology , genetics
Context Experimental studies have shown that maternal hypothyroxinemia during early pregnancy is associated with poor neurodevelopment in affected offspring. Objective The aim of this study was to assess the impact of maternal serum free T4 on psychomotor development of offspring. Materials and methods The study involved 147 women in the third trimester (week 37) of pregnancy. TSH and free T4 serum levels were measured at 37 week gestation. The children were evaluated between 38 and 60 months of age by the McCarthy Scales of Children's Abilities. Results 54.4% of the women had a free T4 below the threshold of hypothyroxinemia. We find a significant effect of maternal hypothyroxinemia on the general cognitive index, and on perceptual‐manipulative and memory coefficients.