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Activation of different neurogenic precursor populations in the hippocampus
Author(s) -
perry f bartlett,
dhanisha j jhaveri,
chanel j taylor
Publication year - 2012
Publication title -
international journal of developmental neuroscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.761
H-Index - 88
eISSN - 1873-474X
pISSN - 0736-5748
DOI - 10.1016/j.ijdevneu.2012.03.330
Subject(s) - hippocampus , neuroscience , neurogenesis , biology
progenitors in the rodent embryonic neocortex (Shitamukai et al., 2011). This cell population is rarely observed in early neurogenic stages and gradually increases in number, reaching the order of 10% of the total self-renewing neuronal progenitors as the brain develops. This low frequency is consistent with infrequent oblique divisions that occur in the developing neocortex. Our results suggest that self-renewing neural progenitors undergo two transitions in the division mode, first, from symmetric to asymmetric divisions of radial glia, and then subsequently from radial glia to OSVZ progenitors by oblique cleavages during neocortical development.