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Brain biomarkers for the development of motor injury in term newborns exposed to chorioamnionitis
Author(s) -
L. Katikaneni,
D. Mulvihill,
C. B. Johnson,
J. Perkel,
D.,
Lambert,
D. Jenkins
Publication year - 2012
Publication title -
international journal of developmental neuroscience
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.761
H-Index - 88
eISSN - 1873-474X
pISSN - 0736-5748
DOI - 10.1016/j.ijdevneu.2012.03.306
Subject(s) - chorioamnionitis , citation , term (time) , full term , medicine , psychology , neuroscience , pediatrics , library science , computer science , biology , pregnancy , fetus , genetics , physics , quantum mechanics
6-dependent activation of JAK/STAT3 signaling in specific subsets of neurons. Furthermore, MIA leads to changes in global transcriptional profiles in the brain, over 90% of which are abrogated in brains of offspring from poly(I:C)-injected IL-6 knockout mothers. These results support a key role for IL-6 in the placenta and fetal brain in shaping neural development and behavior in the MIA offspring.