Brain biomarkers for the development of motor injury in term newborns exposed to chorioamnionitis | Zendy

L.  Katikaneni | Zendy; D.  Mulvihill | Zendy; C. B. Johnson | Zendy; J.  Perkel | Zendy; D. | Zendy; Lambert | Zendy; D.  Jenkins | Zendy

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Brain biomarkers for the development of motor injury in term newborns exposed to chorioamnionitis

Author(s) -

L. Katikaneni,

D. Mulvihill,

C. B. Johnson,

J. Perkel,

D.,

Lambert,

D. Jenkins

Publication year - 2012

Publication title -

international journal of developmental neuroscience

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.761

H-Index - 88

eISSN - 1873-474X

pISSN - 0736-5748

DOI - 10.1016/j.ijdevneu.2012.03.306

Subject(s) - chorioamnionitis , medicine , term (time) , pediatrics , neuroscience , psychology , pregnancy , biology , fetus , genetics , physics , quantum mechanics

6-dependent activation of JAK/STAT3 signaling in specific subsets of neurons. Furthermore, MIA leads to changes in global transcriptional profiles in the brain, over 90% of which are abrogated in brains of offspring from poly(I:C)-injected IL-6 knockout mothers. These results support a key role for IL-6 in the placenta and fetal brain in shaping neural development and behavior in the MIA offspring.

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